Proofpoint Connection Settings

The connection settings to use will depend on your location and which URL you use to login to Proofpoint. 

A copy of this information is available on the Proofpoint Knowledge Base (requires login to access)

LocationUS DatacenterEU Datacenter
IP Addresses 
port 25 for SMTP
port 389/636 for LDAP/LDAPS

1. Routing inbound email from the Internet to Proofpoint

Replace your current MX records with the Proofpoint MX records.

2. Routing outbound email Proofpoint

Configure your on-premise mail server, Office 365 or G-Suite to route outbound email via Proofpoint using the Smarthost in the above table.